The role of sortilin in the “Glut4 Pathway”.
نویسنده
چکیده
ARTICLE HISTORY Received 9 October 2017 Revised 12 October 2017 Accepted 13 October 2017 ABSTRACT Sorting receptor, sortilin, is highly expressed in metabolically active tissues, such as brain, liver, skeletal muscle, and fat. Specifically in adipocytes, sortilin plays an important role in the “Glut4 pathway” by sorting the insulin-responsive glucose transporter, Glut4, in early endosomes and trans-Golgi network and re-routing the transporter from degradation to the recycling pathway.
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